Domain Self-assessment (subjective by patients)

§  Application quality (6 questions; α = 0.73)

§  Assistance quality (2 questions; α = 0.80)

§  Adherence (4 questions; α = 0.58)

Domain characterisation

§  Telephone interview: confidence, degree of effort required, difficulties with removal of needle shield, discomfort with puncture or injection, management of a future s.c. therapy

§  Telephone interview: extent of information received about injection site and injection technique

§  Telephone interview: adherence, adherence to injection time, personal responsibility

Reality (objective by investigators)

§  Application quality (27 questions; α = 0.58)

§  Assistance quality^a

§  Adherence^b

§  Knowledge (10 questions; α = 0.03)^c

§  DOT: Evaluation of every single step from preparation of the injection to the injection itself to the disposal of the syringe

§  SOP (ClinS-I; DailyS-I)

§  Syringe count

§  Telephone interview: consistency with prescription, injection site, recapping, reason for LMWH treatment, potential interactions with LMWH, potential adverse drug reactions of LMWH, action taken if adverse drug reaction occurred